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Nasal Decolonisation / Recurrent Epistaxis

Naseptin Nasal Cream

Brand names: Naseptin

Used in: Epistaxis (Nosebleed)

Naseptin is a nasal cream containing chlorhexidine and neomycin, used to eradicate nasal staphylococci and to treat minor nasal infections such as recurrent epistaxis-associated crusting.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

Chlorhexidine is an antiseptic that disrupts the bacterial cell membrane, while neomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis, together reducing nasal bacterial carriage.

Prescribing in practice

  • It contains peanut (arachis) oil and is contraindicated in patients with peanut or soya allergy.
  • Neomycin can cause local hypersensitivity reactions with prolonged or repeated use.
  • It is applied to the nostrils and is not intended for use elsewhere or for systemic infection.

Monitoring

No laboratory monitoring is needed; review if nasal symptoms persist or if a local allergic reaction develops.

Counselling the patient

  • Do not use this cream if you are allergic to peanuts or soya.
  • Apply gently to the nostrils as directed and complete the course advised.
  • Stop and tell us if you develop a rash, itching or swelling in or around the nose.

Evidence & guidelines

Use reflects its established role in nasal decolonisation; refer to the SPC for the peanut oil contraindication and indications.

Reference: NICE Surgical Site Infection (SSI) Prevention Guidance; PHE MRSA Decolonisation Protocol; Confirm identity and dosing against the manufacturer SPC (eMC) and NICE. Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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