Antispasmodic with Antifoaming Agent (Fixed-Dose Combination)
Alverine Citrate with Simeticone
Brand names: Audmonal
Adult dose
Dose: 1–2 capsules (60 mg alverine / 300 mg simeticone per capsule) 3 times daily before meals
Route: Oral
Frequency: 3 times daily
Clinical pearls
- Combination addresses both IBS spasm (alverine) and bloating/flatulence (simeticone)
- NICE CKS IBS: combination antispasmodics appropriate if bloating is a predominant symptom
- Simeticone is a silicone-based antifoaming agent that breaks down gas bubbles
- No significant difference between alverine alone vs. combination in most trials — use based on symptom profile
- Available as prescription product (Audmonal) in the UK
Contraindications
- Paralytic ileus
- Intestinal obstruction
Side effects
- As per alverine citrate
- Simeticone component is generally inert — minimal side effects
Interactions
- Simeticone may impair absorption of some drugs — administer other medications separately
Monitoring
- IBS symptom response at 4 weeks
- Review if symptoms worsen or alarm features develop
Reference: BNF; NICE CKS IBS (2023); https://bnf.nice.org.uk/drugs/alverine-citrate-with-simeticone/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators