Guanylate cyclase-C agonist
Linaclotide
Brand names: Constella
Adult dose
Dose: 290 micrograms PO OD ≥30 min before food
Route: PO
Frequency: OD
Clinical pearls
- Moderate-severe IBS-C in adults; review benefit at 4 weeks
- NICE TA — limited place per CG61
Contraindications
- GI obstruction
- Inflammatory bowel disease
- Children
Side effects
- Diarrhoea (most common — may be severe)
- Abdominal pain
- Flatulence
Reference: BNF; NICE CG61; https://bnf.nice.org.uk/drugs/linaclotide/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Lower Gastrointestinal Bleed · BSG 2019; NICE NG141
- Variceal Upper GI Bleed · BSG 2015; Baveno VII (2022)
- Spontaneous Bacterial Peritonitis (SBP) · BSG / EASL 2018
- Hepatorenal Syndrome · EASL 2018; ICA 2015
- Hepatic Encephalopathy · EASL 2014; West Haven criteria
- Clostridioides difficile Colitis · NICE NG199 (2021); IDSA/SHEA 2021