Antispasmodic
Mebeverine hydrochloride
Brand names: Colofac
Adult dose
Dose: 135mg TDS 20 min before meals (max 405mg/day)
Route: PO
Frequency: TDS
Clinical pearls
- IBS spasm; symptomatic relief
- Take 20 min before meals
Contraindications
- Paralytic ileus
Side effects
- Allergic reactions
- Tachycardia
- Headache
Reference: BNF; NICE CG61; https://bnf.nice.org.uk/drugs/mebeverine-hydrochloride/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Lower Gastrointestinal Bleed · BSG 2019; NICE NG141
- Variceal Upper GI Bleed · BSG 2015; Baveno VII (2022)
- Spontaneous Bacterial Peritonitis (SBP) · BSG / EASL 2018
- Hepatorenal Syndrome · EASL 2018; ICA 2015
- Hepatic Encephalopathy · EASL 2014; West Haven criteria
- Clostridioides difficile Colitis · NICE NG199 (2021); IDSA/SHEA 2021