PPAR-δ agonist
Seladelpar
Brand names: Livdelzi
Adult dose
Dose: 10mg PO OD (per BNF/SmPC)
Route: PO
Frequency: OD
Clinical pearls
- Primary biliary cholangitis (alternative to obeticholic acid) — specialist hepatology
- Monitor LFTs
Contraindications
- Decompensated cirrhosis
- Hypersensitivity
Side effects
- Headache
- Pruritus
- GI upset
- Hepatotoxicity (signal — under monitoring)
Interactions
- Bile-acid sequestrants (separate by 4h)
- OATP substrates
Monitoring
- LFTs
- ALP
- Bilirubin
Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/seladelpar/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Lower Gastrointestinal Bleed · BSG 2019; NICE NG141
- Variceal Upper GI Bleed · BSG 2015; Baveno VII (2022)
- Spontaneous Bacterial Peritonitis (SBP) · BSG / EASL 2018
- Hepatorenal Syndrome · EASL 2018; ICA 2015
- Hepatic Encephalopathy · EASL 2014; West Haven criteria
- Clostridioides difficile Colitis · NICE NG199 (2021); IDSA/SHEA 2021