Fifth-generation cephalosporin (broad incl MRSA)
Ceftobiprole
Brand names: Mabelio, Zevtera
Adult dose
Dose: 500mg IV q8h (4–14 days)
Route: IV
Frequency: q8h
Clinical pearls
- BSAC: HAP / CAP including MRSA
- UKHSA AMR — specialist use; restricted
Contraindications
- Severe beta-lactam hypersensitivity
Side effects
- GI upset
- Hypersensitivity
- Hyponatraemia
- C. difficile
- Eosinophilia
Interactions
- Limited
Monitoring
- Renal
- Sodium
- C. diff
Reference: BNF; BSAC; UKHSA AMR; SmPC; https://bnf.nice.org.uk/drugs/ceftobiprole/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
Pathways
- Infective Endocarditis · ESC 2023 Infective Endocarditis Guidelines; NICE NG41
- Eczema Herpeticum · BAD; NICE CKS
- Suspected Bacterial Meningitis (Adult) · NICE NG240 (2024); NICE NG143 (paeds)
- Clostridioides difficile Colitis · NICE NG199 (2021); IDSA/SHEA 2021
- Returning Traveller — Fever · NaTHNaC; PHE; ESCMID 2018
- Malaria — Diagnosis & Management · PHE 2016; WHO 2023