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Lincosamide antibiotic

Clindamycin

Brand names: Dalacin C, Dalacin T

Adult dose

Dose: PO 150–450mg QDS. IV/IM 0.6–2.7g/day in 2–4 divided doses (max 4.8g/day)
Route: PO/IV/IM/Topical
Frequency: QDS

Paediatric dose

Dose: 7.5 mg/kg
Route: PO
Frequency: QDS
Max: 450mg/dose
PO 3–6 mg/kg QDS; IV 5–10 mg/kg QDS
Paediatric weight-based calculator

PO 3–6 mg/kg QDS; IV 5–10 mg/kg QDS

Clinical pearls

  • Strong anti-staphylococcal/anaerobic cover; toxin suppression in necrotising soft tissue infections (with penicillin)
  • Highest C. diff risk class — stop if diarrhoea

Contraindications

  • Diarrhoeal states

Side effects

  • C. difficile colitis (high risk — black box)
  • GI upset
  • Rash
  • Hepatotoxicity

Interactions

  • Neuromuscular blockers (potentiation)
  • Erythromycin (antagonism)
  • Live typhoid vaccine

Monitoring

  • LFTs if prolonged
  • FBC

Reference: BNFc; BNF; NICE CKS; https://bnf.nice.org.uk/drugs/clindamycin/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.