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Flucloxacillin + ampicillin

Co-fluampicil

Brand names: Magnapen

Adult dose

Dose: 1 cap (250mg/250mg) QDS, doubled in severe infection

Route: PO/IV

Frequency: QDS

Clinical pearls

Combined gram-positive (S. aureus) + broader cover; use largely superseded
Co-amoxiclav generally preferred

Contraindications

Penicillin hypersensitivity
Cholestatic jaundice with flucloxacillin

Side effects

GI upset
Rash
Cholestatic hepatitis (esp. flucloxacillin)
C. difficile

Interactions

Methotrexate (toxicity)
Warfarin (variable)

Reference: BNF; https://bnf.nice.org.uk/drugs/co-fluampicil/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

Pathways