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PI + booster fixed-dose

Darunavir with cobicistat

Brand names: Rezolsta

Adult dose

Dose: 1 tablet (800/150mg) OD with food
Route: Oral
Frequency: OD

Clinical pearls

  • BHIVA: option for combination ART; co-formulation simplifies dosing
  • Drug-interaction review at every prescription

Contraindications

  • As darunavir
  • CrCl <70 if combined with TAF/TDF
  • Hypersensitivity

Side effects

  • As darunavir; cobicistat causes increased serum creatinine (artefactual)

Interactions

  • As darunavir + cobicistat (potent CYP3A4 inhibitor)

Monitoring

  • VL/CD4
  • Creatinine
  • LFTs
  • Lipids

Reference: BNF; BHIVA HIV guidelines; EACS; https://bnf.nice.org.uk/drugs/darunavir-with-cobicistat/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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