NNRTI (2nd generation)
Etravirine
Brand names: Intelence
Adult dose
Dose: 200mg BD with food
Route: PO
Frequency: BD
Clinical pearls
- Treatment-experienced HIV-1 with NNRTI resistance
- Take with food (raises bioavailability)
Contraindications
- Hypersensitivity
Side effects
- Rash (incl. SJS/TEN — discontinue if severe)
- Hepatotoxicity
- Peripheral neuropathy
- Hyperlipidaemia
Interactions
- Many — efavirenz/rifampicin/St John's wort/carbamazepine reduce levels
- Increases warfarin
- Affects PI/INSTI combinations — consult HIV pharmacist
Monitoring
- Viral load
- CD4
- LFTs
- Lipids
Reference: BNF; BHIVA guidelines; SmPC; https://bnf.nice.org.uk/drugs/etravirine/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Infective Endocarditis · ESC 2023 Infective Endocarditis Guidelines; NICE NG41
- Eczema Herpeticum · BAD; NICE CKS
- Suspected Bacterial Meningitis (Adult) · NICE NG240 (2024); NICE NG143 (paeds)
- Clostridioides difficile Colitis · NICE NG199 (2021); IDSA/SHEA 2021
- Returning Traveller — Fever · NaTHNaC; PHE; ESCMID 2018
- Malaria — Diagnosis & Management · PHE 2016; WHO 2023