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Antifungal (oral)

Griseofulvin

Brand names: Grisol

Adult dose

Dose: 500mg OD or in 2 divided doses with fatty meal; up to 1g/day for severe

Route: PO

Frequency: OD

Clinical pearls

Tinea capitis in children when terbinafine unsuitable
Take with fatty meal for absorption

Contraindications

Severe hepatic impairment
Acute porphyria
Pregnancy
SLE
Concurrent contraceptive needing reliability (reduces efficacy)

Side effects

GI upset
Headache
Photosensitivity
Hepatotoxicity
Leucopenia
Disulfiram-like reaction with alcohol

Interactions

Reduces COC efficacy — additional contraception
Warfarin (variable)
Alcohol
Ciclosporin

Monitoring

LFTs
FBC for prolonged use

Reference: BNF; NICE CKS; https://bnf.nice.org.uk/drugs/griseofulvin/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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