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Interferon

Interferon gamma-1b

Brand names: Imukin

Adult dose

Dose: 50 micrograms/m² SC three times weekly
Route: SC
Frequency: 3×/week

Clinical pearls

  • Chronic granulomatous disease infection prophylaxis; severe malignant osteopetrosis

Contraindications

  • Severe heart failure
  • Severe seizure disorder
  • Hypersensitivity

Side effects

  • Flu-like symptoms
  • Injection site reactions
  • Headache
  • Hepatotoxicity

Interactions

  • Live vaccines

Monitoring

  • LFTs
  • FBC
  • TFTs

Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/interferon-gamma-1b/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.