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CCR5 antagonist

Maraviroc

Brand names: Celsentri

Adult dose

Dose: 150–600mg PO BD per concomitant ARV (refer to BNF)

Route: PO

Frequency: BD

Clinical pearls

Treatment-experienced HIV-1 with CCR5-tropic virus only
Tropism assay essential before initiation

Contraindications

Severe hepatic impairment without adjustment
CCR5-tropism testing required before use

Side effects

Hepatotoxicity (severe — black box)
Postural hypotension
Increased infection risk
Cardiac events
Rash

Interactions

Many — strong CYP3A4 modulators
St John's wort

Monitoring

LFTs
Tropism assay
BP

Reference: BNF; BHIVA; SmPC; https://bnf.nice.org.uk/drugs/maraviroc/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

Pathways