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Long-acting echinocandin

Rezafungin

Brand names: Rezzayo

Adult dose

Dose: 400mg IV loading day 1, then 200mg IV every 7 days
Route: IV
Frequency: weekly

Clinical pearls

  • Invasive candidiasis in adults — once-weekly alternative to caspofungin/anidulafungin
  • Per NICE TA957 — specialist initiation

Contraindications

  • Hypersensitivity to echinocandins

Side effects

  • Infusion reactions
  • Hypokalaemia
  • Phototoxicity
  • Hepatotoxicity
  • Headache

Interactions

  • No clinically significant CYP/P-gp

Monitoring

  • LFTs
  • K+

Reference: BNF; NICE TA957; SmPC; https://bnf.nice.org.uk/drugs/rezafungin/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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