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NNRTI (HIV)

Rilpivirine

Brand names: Edurant

Adult dose

Dose: 25mg PO OD with food
Route: PO
Frequency: OD

Clinical pearls

  • HIV-1 in treatment-naive with VL ≤100,000 and CD4 >200
  • Take with full meal (300+ kcal); long-acting cabotegravir+rilpivirine for maintenance

Contraindications

  • Concurrent strong CYP3A4 inducers
  • PPIs (avoid)
  • HIV viral load >100,000 copies/mL at initiation

Side effects

  • Insomnia
  • Headache
  • Depression
  • Hepatotoxicity
  • QT prolongation
  • Severe skin reactions

Interactions

  • PPIs (avoid)
  • H2 blockers (separate by 12h)
  • Antacids
  • Strong CYP3A4 modulators

Monitoring

  • HIV VL/CD4
  • LFTs

Reference: BNF; BHIVA; https://bnf.nice.org.uk/drugs/rilpivirine/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

Pathways