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Carboxypenicillin (β-lactamase stable)

Temocillin

Brand names: Negaban

Adult dose

Dose: 1–2g IV/IM BD-TDS

Route: IV/IM

Frequency: BD-TDS

Dose adjustments

Renal

Reduce in renal impairment

Clinical pearls

ESBL-producing Enterobacterales infections, complicated UTI — carbapenem-sparing
Per UKHSA AMR guidance

Contraindications

Penicillin allergy
Hypersensitivity

Side effects

Diarrhoea
C. difficile infection
Rash
Cytopenias
Hepatotoxicity

Interactions

Methotrexate
Probenecid
Warfarin

Monitoring

FBC
U&E
LFTs

Reference: BNF; UKHSA AMR; https://bnf.nice.org.uk/drugs/temocillin/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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