Selective oestrogen receptor modulator (SERM)
Ospemifene
Brand names: Senshio
Adult dose
Dose: 60mg PO OD with food
Route: PO
Frequency: OD
Clinical pearls
- Moderate-severe symptomatic vulvovaginal atrophy in postmenopausal women not suitable for local oestrogen
- Take with food (improves absorption)
Contraindications
- VTE history
- Active oestrogen-dependent cancer
- Undiagnosed vaginal bleeding
- Endometrial hyperplasia
- Severe hepatic impairment
- Pregnancy
Side effects
- Hot flushes
- Vaginal discharge
- Muscle spasms
- Endometrial hyperplasia/proliferation (theoretical)
- VTE
Interactions
- Strong CYP3A4/2C9 modulators
- Oestrogens (avoid)
Reference: BNF; NICE TA876; SmPC; https://bnf.nice.org.uk/drugs/ospemifene/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs