Selective oestrogen receptor modulator (SERM)
Toremifene
Brand names: Fareston
Adult dose
Dose: 60mg PO OD
Route: PO
Frequency: OD
Clinical pearls
- ER-positive metastatic breast cancer in postmenopausal women
- Tamoxifen alternative; ECG monitoring
Contraindications
- QT prolongation
- Endometrial hyperplasia
- Severe hepatic impairment
- Pregnancy
- Concurrent QT-prolonging drugs
Side effects
- Hot flushes
- VTE
- QT prolongation
- Endometrial cancer
- Hepatotoxicity
- Cataracts
Interactions
- QT-prolonging drugs
- CYP3A4 modulators
- Warfarin
Monitoring
- ECG
- LFTs
- Endometrial symptoms
Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/toremifene/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs