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Short-acting benzodiazepine

Oxazepam

Adult dose

Dose: Anxiety: 15–30mg TDS-QDS. Insomnia: 15–25mg at bedtime
Route: PO
Frequency: TDS-QDS

Clinical pearls

  • Glucuronide metabolism — useful in hepatic impairment
  • Limit duration to ≤2–4 weeks

Contraindications

  • Severe respiratory disease
  • Sleep apnoea
  • Severe hepatic impairment
  • Myasthenia gravis

Side effects

  • Sedation
  • Confusion in elderly
  • Dependence
  • Falls
  • Withdrawal symptoms

Interactions

  • CNS depressants
  • Alcohol

Reference: BNF; NICE TA77; https://bnf.nice.org.uk/drugs/oxazepam/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.