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First-generation antipsychotic (phenothiazine)

Pericyazine

Brand names: Neulactil

Adult dose

Dose: Schizophrenia: 75mg/day in divided doses initially, max 300mg/day. Adjunct in severe anxiety/disturbed behaviour: 15–30mg/day in divided doses

Route: PO

Frequency: divided

Clinical pearls

Less commonly used; high anticholinergic burden
Avoid in elderly with dementia

Contraindications

CNS depression
Phaeochromocytoma
Bone marrow depression

Side effects

Sedation
Anticholinergic effects
Postural hypotension
Extrapyramidal effects
QT prolongation
Hyperprolactinaemia

Interactions

CNS depressants
QT-prolonging drugs
Antimuscarinics
Levodopa

Monitoring

BP
ECG
Glucose
Lipids
Prolactin

Reference: BNF; NICE CG178; https://bnf.nice.org.uk/drugs/pericyazine/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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