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First-generation antipsychotic (substituted benzamide)

Sulpiride

Brand names: Dolmatil, Sulpor

Adult dose

Dose: Schizophrenia: 200–400mg PO BD (max 2.4g/day). Tourette's: 100–400mg PO BD

Route: PO

Frequency: BD

Dose adjustments

Renal

Reduce in renal impairment

Clinical pearls

Schizophrenia, Tourette's
Less sedating; high-dose required for psychosis

Contraindications

Phaeochromocytoma
Prolactin-dependent tumour
Acute porphyria

Side effects

EPS
Sedation
Hyperprolactinaemia (very common — galactorrhoea, amenorrhoea)
QT prolongation
Weight gain
Anticholinergic effects (less than typicals)

Interactions

QT-prolonging drugs
Levodopa
Antacids (separate)

Monitoring

ECG
Glucose
Lipids
Prolactin
Weight

Reference: BNF; NICE CG178; https://bnf.nice.org.uk/drugs/sulpiride/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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