Anti-IL-2 receptor monoclonal antibody (induction immunosuppression)
Basiliximab
Brand names: Simulect
Adult dose
Dose: 20mg IV within 2h pre-transplant; second dose 20mg IV day 4 post-transplant
Route: IV
Frequency: 2 doses
Clinical pearls
- NICE TA99 / KDIGO transplant guidance: induction therapy for renal transplant — reduces acute rejection vs steroid-only induction
- BTS / NHSBT guidelines
- Specialist transplant centre
Contraindications
- Pregnancy
- Breastfeeding
- Hypersensitivity
Side effects
- Hypersensitivity / anaphylaxis (rare)
- Cytokine release syndrome
- Infections
- Constipation
- Headache
Interactions
- Other immunosuppressives (additive)
- Live vaccines
Monitoring
- Hypersensitivity
- Infections
- Renal graft function
Reference: BNF; NICE TA99; KDIGO transplant; BTS/NHSBT; SmPC; https://bnf.nice.org.uk/drugs/basiliximab/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Simplified Autoimmune Hepatitis Score · Liver Disease
- Revised Original International Autoimmune Hepatitis Score (IAIHG) · Autoimmune Liver Disease
- Ho Index for Predicting Response to Medical Therapy in IBD · Inflammatory Bowel Disease
- Myasthenia Gravis Activities of Daily Living (MG-ADL) Scale · Neuromuscular
- Bishop Score · Labour & Delivery
- Modified Bishop Score for Cervical Ripeness · Labour & Delivery