gi-hepatology

Revised Original International Autoimmune Hepatitis Score (IAIHG)

The revised original scoring system from the International Autoimmune Hepatitis Group (IAIHG) for diagnosing autoimmune hepatitis (AIH). Unlike the simplified score (which is point-of-care), the revised original score uses detailed serological, histological, and treatment response data. Pre-treatment score above 15 = definite AIH; 10-15 = probable AIH. Developed by Alvarez et al. 1999.

Sex*

ALP/AST (or ALP/ALT) ratio*

Gamma-globulin or IgG above upper limit of normal (ULN)*

ANA, SMA, or anti-LKM-1 antibody titre*

AMA (anti-mitochondrial antibody) -- suggestive of PBC rather than AIH*

Hepatitis viral markers*

History of hepatotoxic drug use*

Alcohol intake*

Liver biopsy histology*

Other autoimmune disease in patient or first-degree relative*

References

Alvarez F et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol. 1999;31(5):929-938.
EASL Clinical Practice Guidelines: Autoimmune Hepatitis. J Hepatol. 2015;63(4):971-1004.

Curated clinical cross-links plus same-class fallbacks.

Drugs

Pathways

Decision support only — verify against MDCalc, NICE, or your local guideline before clinical use.

References

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