Taxane (specialist)
Cabazitaxel
Brand names: Jevtana
Adult dose
Dose: 25mg/m² IV q3w (with prednisolone)
Route: IV
Frequency: q3w
Clinical pearls
- NICE TA391: metastatic castration-resistant prostate cancer post-docetaxel
- ESMO prostate cancer guidelines
- Premedication with antihistamine, H2 blocker, corticosteroid (hypersensitivity prophylaxis)
Contraindications
- Neutrophils <1.5
- Severe hepatic impairment
- Hypersensitivity to taxanes / polysorbate 80
- Pregnancy
Side effects
- Myelosuppression (febrile neutropenia common — primary G-CSF often)
- Diarrhoea (severe)
- Hypersensitivity
- Fatigue
- Peripheral neuropathy
- Renal failure
Interactions
- Strong CYP3A4 inhibitors/inducers
Monitoring
- FBC (G-CSF often co-administered)
- LFTs
- Renal function
- Diarrhoea
Reference: BNF; NICE TA391; ESMO; SmPC; https://bnf.nice.org.uk/drugs/cabazitaxel-specialist-drug/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.