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Antifibrinolytic — Surgical Haemostasis (Alternative to Tranexamic Acid)

Aminocaproic Acid

Brand names: Amicar

Aminocaproic acid is an antifibrinolytic agent used to treat or prevent excessive bleeding caused by hyperfibrinolysis.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It inhibits fibrinolysis by blocking the binding of plasminogen and plasmin to fibrin, thereby stabilising clots and reducing their breakdown.

Prescribing in practice

  • Avoid use when there is active intravascular clotting or disseminated intravascular coagulation unless given with appropriate anticoagulation, because of thrombotic risk.
  • Use with caution in renal impairment and in the presence of haematuria from an upper urinary tract source, where clot retention may occur.
  • It is closely related in action to tranexamic acid, which is more commonly used in UK practice.

Monitoring

Monitor for signs of thrombosis and review for resolution of bleeding, with caution in renal impairment.

Counselling the patient

  • This medicine helps reduce bleeding by slowing the breakdown of blood clots.
  • Report any leg pain, swelling, chest pain or breathlessness promptly.
  • Tell the team about any kidney problems or blood in the urine.

Evidence & guidelines

Antifibrinolytic therapy is an established approach to reducing bleeding in hyperfibrinolytic states.

Reference: MHRA SPC Amicar; BSH Perioperative Haemostasis Guidelines; Perioperative Antifibrinolytic Review; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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