ToxicologyEmergencyHepatology
Mushroom poisoning
Syndromic approach to mushroom ingestion, with emphasis on amatoxin (Amanita phalloides) hepatotoxicity.
Source: TOXBASE/NPIS; AACT/EAPCCT; EASL
Step 1 of ~8
action
Time-of-onset is the key clue
Use latency to triage:
• <6 h: usually GI-only (Russula, Boletus, Amanita muscaria muscarinic, hallucinogenic Psilocybe). Generally lower risk — but does NOT exclude later amatoxin (mixed ingestions reset the clock).
• 6–24 h: amatoxin (Amanita phalloides, virosa, verna; Galerina; Lepiota) — life-threatening.
• 24 h–14 days: orellanine (Cortinarius — renal failure 1–3 weeks); gyromitrin (Gyromitra esculenta — hepato-CNS).
ABCDE; bloods: FBC, U&E, creatinine, LFTs (ALT, ALP, bilirubin), INR, glucose, lactate, paracetamol/salicylate, VBG.
Attempt to identify mushroom: photograph cap, gills, stem, base, habitat; preserve any uneaten mushroom or vomitus for mycologist (RBG Kew or local mycological society). Multiple species per ingestion is common — assume amatoxin if any uncertainty.
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- AcetylcysteineRecommendedMucolytic / Paracetamol overdose antidote
- AtropineRecommendedAnticholinergic
- LorazepamRecommendedBenzodiazepine
Same class
Pathways
- Paracetamol overdose · TOXBASE/NPIS; MHRA DSU 2012/2024; SNAP regimen (Lancet 2014); BNF
- TCA overdose · TOXBASE/NPIS; AACT/EAPCCT position statements; Resuscitation Council UK ALS
- Opioid overdose · TOXBASE/NPIS; Resuscitation Council UK; BNF
- Anticholinergic toxidrome · TOXBASE/NPIS; AACT/EAPCCT; BNF
- Benzodiazepine overdose · TOXBASE/NPIS; AACT/EAPCCT; BNF
- β-blocker overdose · TOXBASE/NPIS; AACT/EAPCCT; ESC; BNF
Decision support only. Always apply local guidelines and clinical judgement.