Combined analgesic + antihistamine + opioid
Paracetamol with buclizine and codeine
Brand names: Migraleve
Adult dose
Dose: Pink: 2 tabs at onset; Yellow: 2 tabs every 4h (max 6 yellow + 2 pink/24h)
Route: PO
Frequency: PRN
Clinical pearls
- Migraine with nausea — short-term symptomatic relief
- Avoid frequent use (medication-overuse headache)
Contraindications
- Children <12
- Acute respiratory depression
- Hepatic impairment
- Pregnancy/breastfeeding
Side effects
- Drowsiness
- Constipation
- Anticholinergic effects
- Paracetamol overdose risk
Interactions
- CNS depressants
- MAOIs
- CYP2D6 inhibitors
Reference: BNF; NICE CG150; https://bnf.nice.org.uk/drugs/paracetamol-with-buclizine-hydrochloride-and-codeine-phosphate/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Morphine Milligram Equivalents (MME) Calculator · Pain / Opioids
- Opioid Conversion / Equianalgesic Guide · Pain Management
- Urticaria Activity Score (UAS7) · Urticaria
- Rumack-Matthew Nomogram · Toxicology
- Numeric Rating Scale (NRS) Pain Assessment and Management · Pain Management
- King's College Criteria for Acute Liver Failure · Prognosis
Pathways
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines
- Syncope Assessment · ESC 2018 Syncope Guidelines; NICE NG109
- Acute Chest Pain · NICE CG95; ESC 2023 ACS Guidelines