Combined analgesic + sympathomimetic
Paracetamol with isometheptene
Brand names: Midrid (discontinued)
Adult dose
Dose: Per BNF — historically 2 caps at onset, 1 every hour as needed (max 5/12h)
Route: PO
Frequency: PRN
Clinical pearls
- Migraine; product largely withdrawn in UK
Contraindications
- Severe cardiovascular disease
- Hypertension
- Glaucoma
- MAOI within 14 days
Side effects
- Hypertension
- Tachycardia
- Dizziness
- Paracetamol overdose risk
Interactions
- MAOIs
- Sympathomimetics
- TCAs
Reference: BNF; https://bnf.nice.org.uk/drugs/paracetamol-with-isometheptene/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Rumack-Matthew Nomogram · Toxicology
- Numeric Rating Scale (NRS) Pain Assessment and Management · Pain Management
- King's College Criteria for Acute Liver Failure · Prognosis
- Kings College Criteria for Paracetamol Toxicity · Hepatology
- FAST Exam Protocol — Focused Assessment with Sonography in Trauma · Trauma
Pathways
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines
- Syncope Assessment · ESC 2018 Syncope Guidelines; NICE NG109
- Acute Chest Pain · NICE CG95; ESC 2023 ACS Guidelines