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Second-generation H1-antihistamine + PAF antagonist

Rupatadine

Brand names: Rupafin

Adult dose

Dose: 10mg PO OD

Route: PO

Frequency: OD

Clinical pearls

Allergic rhinitis, chronic urticaria
Dual mechanism (PAF) may help allergic rhinitis with congestion

Contraindications

Severe hepatic/renal impairment
Concurrent strong CYP3A4 inhibitors
Hypersensitivity

Side effects

Drowsiness
Headache
QT prolongation (rare)
Asthenia

Interactions

Strong CYP3A4 inhibitors
CNS depressants
Grapefruit juice

Monitoring

Symptoms

Reference: BNF; SmPC; https://bnf.nice.org.uk/drugs/rupatadine/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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