haematology
R2-ISS — Second Revision International Staging System for Multiple Myeloma
Updated staging for newly-diagnosed multiple myeloma (D'Agostino, IMS 2022). Adds 1q+ to ISS, LDH and high-risk cytogenetics. Stratifies four risk groups (Low / Low-intermediate / Intermediate-high / High).
References
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Phenytoin / Fosphenytoin · Antiepileptic — Status Epilepticus (Second-Line)
- Levetiracetam (IV) · Antiepileptic — Status Epilepticus (Second-Line)
- Cetirizine · Second-generation antihistamine (H1 antagonist)
- Fexofenadine 120mg / 180mg Tablets · Second-generation (non-sedating) antihistamine — H1 antagonist
- Loratadine 10mg Tablets · Second-generation (non-sedating) antihistamine — H1 antagonist
- Acrivastine · Antihistamine (H1, second-generation)
Pathways
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO
Decision support only — verify against MDCalc, NICE, or your local guideline before clinical use.