Antidiarrhoeal (kaolin) + opioid
Kaolin with morphine
Brand names: Kaolin and Morphine Mixture BP
Adult dose
Dose: 10mL TDS-QDS PRN
Route: PO
Frequency: PRN
Clinical pearls
- Symptomatic uncomplicated diarrhoea (older preparation; loperamide preferred)
Contraindications
- Children <12
- Acute UC
- Diarrhoea due to invasive bacterial infection
- Paralytic ileus
- Acute liver disease
Side effects
- Constipation
- Drowsiness
- Dependence (low — small morphine content)
- Anticholinergic effects
Interactions
- CNS depressants
- MAOIs
Reference: BNF; https://bnf.nice.org.uk/drugs/kaolin-with-morphine/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- Morphine Milligram Equivalents (MME) Calculator · Pain / Opioids
- Opioid Conversion / Equianalgesic Guide · Pain Management
- Numeric Rating Scale (NRS) Pain Assessment and Management · Pain Management
- Finnegan Neonatal Abstinence Scoring Tool (FNAST) · Neonatal Abstinence Syndrome
- Modified Finnegan Neonatal Abstinence Score (NAS) · Neonatal
- FAST Exam Protocol — Focused Assessment with Sonography in Trauma · Trauma
Pathways
- Sepsis Screening and Sepsis Six · UK Sepsis Trust; NICE NG51; Surviving Sepsis Campaign 2021
- Unintentional Weight Loss Workup · NICE NG12; BSG
- Chronic Fatigue Workup · NICE NG206; BMJ Best Practice
- Lymphadenopathy Workup · NICE NG12; BMJ Best Practice
- Pre-op Medical Clearance · NICE NG45; ESC 2022
- Secondary Hypertension Workup · NICE NG136; ESH 2023