Trace element
Selenium
Adult dose
Dose: Deficiency/PN: 60–100 micrograms IV/PO daily as part of trace-element supplementation
Route: PO/IV
Frequency: OD
Clinical pearls
- Routinely included in PN trace-element solutions
- Long-term TPN deficiency → cardiomyopathy
Contraindications
- Hypersensitivity
- Selenium toxicity
Side effects
- Selenosis (high doses — alopecia, nail changes, neuropathy)
- GI upset
Interactions
- Vitamin C (reduces absorption)
Monitoring
- Selenium levels (long-term TPN)
Reference: BNF; BAPEN; NICE NG32; https://bnf.nice.org.uk/drugs/selenium/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Sepsis Screening and Sepsis Six · UK Sepsis Trust; NICE NG51; Surviving Sepsis Campaign 2021
- Unintentional Weight Loss Workup · NICE NG12; BSG
- Chronic Fatigue Workup · NICE NG206; BMJ Best Practice
- Lymphadenopathy Workup · NICE NG12; BMJ Best Practice
- Pre-op Medical Clearance · NICE NG45; ESC 2022
- Secondary Hypertension Workup · NICE NG136; ESH 2023