ClinCalc Pro
Menu
Calculators Drugs Pathways AI Dx Donate Get the App
Synthetic factor Xa inhibitor

Fondaparinux sodium

Brand names: Arixtra

Adult dose

Dose: VTE prophylaxis: 2.5mg SC OD. VTE treatment: 5mg (<50kg)/7.5mg (50–100kg)/10mg (>100kg) SC OD. UA/NSTEMI: 2.5mg SC OD
Route: SC
Frequency: OD

Dose adjustments

Renal

CrCl 20–50: reduce or use with caution. CrCl <20: avoid

Clinical pearls

  • Alternative to heparin in heparin-induced thrombocytopenia (HIT)
  • No specific antidote

Contraindications

  • Active major bleeding
  • CrCl <20
  • Bacterial endocarditis
  • Severe renal impairment for treatment doses

Side effects

  • Bleeding
  • Anaemia
  • Thrombocytopenia (less HIT than heparin)
  • Injection site reaction

Interactions

  • Other anticoagulants/antiplatelets — bleeding

Monitoring

  • U&E
  • Hb
  • Platelets

Reference: BNF; NICE NG89/NG185; ESC ACS guidelines; https://bnf.nice.org.uk/drugs/fondaparinux-sodium/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

Calculators
Pathways