Emergency MedicineHaematologySurgery
Major Haemorrhage / Massive Transfusion
Major Haemorrhage / Massive Transfusion clinical pathway.
Source: BCSH; RCOA; RCEM; RCS — BCSH Guidelines
Used in: Anaemia
Step 1 of ~4
info
Activation
Assessment:
Related
Curated clinical cross-links plus same-class fallbacks.
Drugs
- Methylene Blue · Guanylate Cyclase / Nitric Oxide Pathway Inhibitor
- Alteplase (tPA) · Thrombolytic — Ischaemic Stroke / Massive PE
- Sodium phenylbutyrate · Ammonia scavenger (alternative pathway)
- Marstacimab · Anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody
- Glasdegib (Specialist drug) · Hedgehog pathway inhibitor
- Vismodegib (Specialist drug) · Hedgehog pathway (SMO) inhibitor
Pathways
- Difficult Airway Algorithm (DAS) · DAS 2015; Royal College of Anaesthetists
- Major Haemorrhage Protocol · NICE NG24; UK MHP guidelines
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines
Featured in these MRCEM clinical pathways
A deeper exam-focused version of this pathway is available on our sister siteReviseMRCEM.
MRCEM Primary / Intermediate / OSCE candidates: each pathway includes exam-style questions, RCEM/NICE citations, and FAQ summaries.
Decision support only. Always apply local guidelines and clinical judgement.