Recombinant G-CSF
Lenograstim
Brand names: Granocyte
Adult dose
Dose: 150 micrograms/m² SC OD until neutrophil recovery
Route: SC/IV
Frequency: OD
Clinical pearls
- Chemotherapy-induced neutropenia, stem cell mobilisation, severe chronic neutropenia
Contraindications
- Hypersensitivity
- Severe congenital neutropenia (caution)
Side effects
- Bone pain
- Splenomegaly/rupture
- Capillary leak
- ARDS (rare)
- Cutaneous vasculitis
Interactions
- Live vaccines
- Lithium (potentiation)
Monitoring
- FBC
- Spleen size
- Bone pain
Reference: BNF; NICE; https://bnf.nice.org.uk/drugs/lenograstim/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO