Indanedione anticoagulant (vitamin K antagonist)
Phenindione
Brand names: Dindevan
Adult dose
Dose: Loading 200mg day 1, 100mg day 2, then maintain by INR (typically 50–150mg/day)
Route: PO
Frequency: OD
Clinical pearls
- Reserved for warfarin-intolerant patients
- Many drug interactions and idiosyncratic ADRs
Contraindications
- Pregnancy
- Active bleeding
- Severe hepatic/renal impairment
- Hypersensitivity
Side effects
- Bleeding
- Pink/orange urine discolouration
- Hepatotoxicity
- Agranulocytosis
- Rash
- Hypersensitivity
Interactions
- Many — see BNF Appendix 1
- NSAIDs
- Antibiotics
- Amiodarone
Monitoring
- INR
- FBC
- LFTs
Reference: BNF; https://bnf.nice.org.uk/drugs/phenindione/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO