Vitamin B1
Thiamine
Brand names: Pabrinex (combo)
Adult dose
Dose: Wernicke's prophylaxis: Pabrinex 1 pair IV TDS x3-5 days. Treatment: 2 pairs IV TDS x3 days. PO maintenance: 100mg TDS
Route: PO/IV
Frequency: per indication
Clinical pearls
- Alcohol withdrawal, refeeding syndrome, Wernicke's encephalopathy
- Always give before glucose in alcohol-dependence
Contraindications
- Hypersensitivity (rare anaphylaxis with IV)
Side effects
- Anaphylaxis (rare — IV)
- Injection-site irritation
Interactions
- No clinically significant
Monitoring
- Symptoms (ataxia, ophthalmoplegia, confusion)
Reference: BNF; NICE CG100/NG32; https://bnf.nice.org.uk/drugs/thiamine/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Sepsis Screening and Sepsis Six · UK Sepsis Trust; NICE NG51; Surviving Sepsis Campaign 2021
- Unintentional Weight Loss Workup · NICE NG12; BSG
- Chronic Fatigue Workup · NICE NG206; BMJ Best Practice
- Lymphadenopathy Workup · NICE NG12; BMJ Best Practice
- Pre-op Medical Clearance · NICE NG45; ESC 2022
- Secondary Hypertension Workup · NICE NG136; ESH 2023