Hyperimmune globulin
Cytomegalovirus immunoglobulin
Brand names: Cytotect
Adult dose
Dose: Per SmPC indication (e.g., transplant prophylaxis 1mL/kg)
Route: IV
Frequency: Per protocol
Clinical pearls
- Solid organ transplant CMV prevention/treatment (specialist transplant centres) — adjunct to ganciclovir / valganciclovir
- BTS thoracic transplant guidance
- UKHSA Green Book ch 11 (passive immunisation)
Contraindications
- IgA deficiency with anti-IgA
- Hypersensitivity
Side effects
- Infusion reactions
- Headache
- Fever
- Anaphylaxis
- Aseptic meningitis (rare)
- Renal impairment
- Thromboembolism
Interactions
- Live vaccines (defer 3 months post-IVIG)
Monitoring
- Renal function
- BP during infusion
- Anaphylaxis
- CMV viral load
Reference: BNF; UKHSA Green Book ch 11; transplant unit protocols; https://bnf.nice.org.uk/drugs/cytomegalovirus-immunoglobulin/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Infective Endocarditis · ESC 2023 Infective Endocarditis Guidelines; NICE NG41
- Eczema Herpeticum · BAD; NICE CKS
- Suspected Bacterial Meningitis (Adult) · NICE NG240 (2024); NICE NG143 (paeds)
- Clostridioides difficile Colitis · NICE NG199 (2021); IDSA/SHEA 2021
- Returning Traveller — Fever · NaTHNaC; PHE; ESCMID 2018
- Malaria — Diagnosis & Management · PHE 2016; WHO 2023