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Fluorocycline antibiotic (tetracycline class)

Eravacycline

Brand names: Xerava

Eravacycline is a fluorocycline (tetracycline-class) intravenous antibacterial used for complicated intra-abdominal infections in adults.

Dosing — being independently re-sourced

ClinCalc Pro is rebuilding its dose data from primary open sources — the manufacturer SmPC (eMC), the WHO Model Formulary and other official references — under clinician review. This drug's structured dose is not yet published here. Confirm all doses against the product SmPC and your local formulary before prescribing.

Clinical monograph

How it works

It binds to the bacterial 30S ribosomal subunit and inhibits protein synthesis, with activity against many Gram-positive, Gram-negative and anaerobic organisms including some multidrug-resistant strains.

Prescribing in practice

  • As a tetracycline-class agent it can cause permanent tooth discolouration and affect skeletal development, so it is avoided in pregnancy and in young children.
  • Infusion-related reactions and gastrointestinal upset (nausea, vomiting) are common.
  • It should be used in line with antimicrobial stewardship and local microbiology advice to preserve activity against resistant organisms.

Monitoring

Monitor clinical response, infusion-site and hypersensitivity reactions, and gastrointestinal tolerability.

Counselling the patient

  • Report any severe or watery diarrhoea, which may indicate a bowel infection.
  • Tell the team if you are or might be pregnant.
  • Report any rash, swelling or difficulty breathing during the infusion.

Evidence & guidelines

Eravacycline's efficacy in complicated intra-abdominal infection was demonstrated in the IGNITE programme of non-inferiority trials.

Reference: BSAC; UKHSA AMR guidance; SmPC; Drug verified in RxNorm (NLM); confirm dosing against the manufacturer SPC (eMC). Verify against your local formulary and current prescribing references before prescribing. Monograph status: clinician-reviewed (2026-07-04).

Related

Curated clinical cross-links plus same-class fallbacks.

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