Fluorocycline antibiotic (tetracycline class)
Eravacycline
Brand names: Xerava
Adult dose
Dose: 1mg/kg IV BD
Route: IV
Frequency: BD
Clinical pearls
- Complicated intra-abdominal infections — second-line per BSAC
- Active against many MDR pathogens including ESBL Enterobacteriaceae and CRE
- Stewardship-restricted; specialist microbiology approval
Contraindications
- Hypersensitivity to tetracyclines
- Pregnancy
- Children <8 years
Side effects
- Nausea/vomiting
- Infusion-site reactions
- Tooth discolouration in young children
- Photosensitivity
- C. difficile colitis
- Pancreatitis (rare)
Interactions
- Strong CYP3A4 inducers (reduce levels)
- Anticoagulants
Monitoring
- Renal/LFTs
- C. diff surveillance
Reference: BNF; BSAC; UKHSA AMR guidance; SmPC; https://bnf.nice.org.uk/drugs/eravacycline/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Calculators
- NYHA Heart Failure Classification · Heart Failure
- GRACE ACS Risk Score · Acute Coronary Syndrome
- MAGGIC Heart Failure Risk Score · Heart Failure
- WHO Functional Classification (Pulmonary Hypertension) · Pulmonary Hypertension
- Centor / McIsaac Score for Strep Pharyngitis · Throat
- FeverPAIN Score for Strep Throat · Throat
Pathways
- Infective Endocarditis · ESC 2023 Infective Endocarditis Guidelines; NICE NG41
- Eczema Herpeticum · BAD; NICE CKS
- Suspected Bacterial Meningitis (Adult) · NICE NG240 (2024); NICE NG143 (paeds)
- Clostridioides difficile Colitis · NICE NG199 (2021); IDSA/SHEA 2021
- Returning Traveller — Fever · NaTHNaC; PHE; ESCMID 2018
- Malaria — Diagnosis & Management · PHE 2016; WHO 2023