Interferon Beta-1a

How it works

It modulates the immune response, reducing pro-inflammatory cytokine activity and lymphocyte migration into the central nervous system, which lowers inflammatory demyelination.

Prescribing in practice

• Monitor for hepatic injury, as raised transaminases and rare serious liver dysfunction can occur, and check liver function before and during treatment.
• Flu-like symptoms are common early in therapy and can be reduced with gradual titration and antipyretic cover.
• Use with caution in patients with depression, seizure disorders or thyroid dysfunction.

Monitoring

Monitor full blood count, liver function and thyroid function tests periodically during treatment.

Counselling the patient

• Rotate injection sites and watch for skin reactions or signs of injection-site necrosis.
• Expect flu-like symptoms early on that usually settle with time.
• Report low mood, jaundice or unexplained bleeding to your team.

Evidence & guidelines

Interferon beta-1a is supported by pivotal trials demonstrating reduced relapse frequency and disability progression in relapsing-remitting multiple sclerosis.