RoPE Score for Patent Foramen Ovale
Estimates probability that a patent foramen ovale (PFO) is responsible for a cryptogenic stroke. Higher score = PFO more likely to be causal.
Score interpretation
RoPE 0–3: PFO likely incidental (~43% attributable fraction). Other stroke aetiology probable.
→ Comprehensive stroke workup. PFO closure less likely to benefit this patient.
RoPE 4–6: Intermediate probability PFO is causal (~43–66% attributable fraction).
→ Consider PFO closure if recurrent cryptogenic stroke. Cardiology and Neurology MDT.
RoPE 7–10: PFO likely causative of stroke (~72–88% attributable fraction).
→ Strong consideration for PFO closure. Cardiology referral. Antiplatelet therapy pending decision.
Interpretation bands for the RoPE. Apply clinical judgement and local guidance.
References
- Kent DM et al. An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke. Neurology. 2013;81(7):619-625.
Related
Curated clinical cross-links plus same-class fallbacks.
- Acute Heart Failure · ESC 2021 Heart Failure Guidelines; NICE NG106
- NSTEMI / Unstable Angina · ESC 2020 NSTEMI Guidelines; NICE NG185
- New-Onset Atrial Fibrillation · ESC 2020 AF Guidelines; NICE NG196
- Hypertensive Emergency · ESC/ESH 2018 Hypertension Guidelines; NICE NG136
- Bradycardia Management · Resuscitation Council UK ABCDE; ESC 2021 Pacing Guidelines
- Ventricular Tachycardia / Fibrillation · Resuscitation Council UK ACLS; ESC 2022 Ventricular Arrhythmia Guidelines
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.