Recombinant hCG
Choriogonadotropin alfa
Brand names: Ovitrelle
Adult dose
Dose: 250 micrograms (6500 IU) SC as single dose 24–48h after follicle maturation
Route: SC
Frequency: once per cycle
Clinical pearls
- Triggers final follicular maturation in IVF/ART
Contraindications
- Tumours of pituitary/hypothalamus
- Hormone-dependent tumour
- Uncontrolled thyroid/adrenal dysfunction
- Pregnancy
- Ovarian cyst
Side effects
- OHSS
- Headache
- Fatigue
- Injection site reaction
Reference: BNF; https://bnf.nice.org.uk/drugs/choriogonadotropin-alfa/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Spinal Anaesthesia Hypotension Management · AAGBI; ASA
- Pre-Eclampsia / Eclampsia in ED · NICE NG133; RCOG Green-top 10A
- Suspected Ectopic Pregnancy · NICE NG126; RCOG Green-top 21
- Polycystic Ovary Syndrome (PCOS) · International PCOS Guideline 2023; NICE CKS
- Pre-eclampsia Management · NICE NG133 2019
- Ectopic Pregnancy · NICE CG154 / RCOG GTG 21