Selective oestrogen receptor modulator
Clomifene citrate
Brand names: Clomid
Adult dose
Dose: 50mg OD for 5 days starting day 2–5 of cycle. May increase to 100mg in subsequent cycles. Max 6 cycles
Route: PO
Frequency: OD x 5 days
Clinical pearls
- Anovulatory infertility (esp. PCOS)
- Limit to ≤6 cycles to minimise ovarian cancer risk
- Pre-treatment ovulation work-up required
Contraindications
- Pregnancy
- Hepatic impairment
- Ovarian cyst (other than PCOS)
- Hormone-dependent tumour
- Undiagnosed abnormal uterine bleeding
Side effects
- Hot flushes
- Mood changes
- Visual disturbance
- Multiple pregnancy
- OHSS
Monitoring
- Ultrasound + LH/progesterone to confirm ovulation
Reference: BNF; NICE CG156; https://bnf.nice.org.uk/drugs/clomifene-citrate/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Spinal Anaesthesia Hypotension Management · AAGBI; ASA
- Pre-Eclampsia / Eclampsia in ED · NICE NG133; RCOG Green-top 10A
- Suspected Ectopic Pregnancy · NICE NG126; RCOG Green-top 21
- Polycystic Ovary Syndrome (PCOS) · International PCOS Guideline 2023; NICE CKS
- Pre-eclampsia Management · NICE NG133 2019
- Ectopic Pregnancy · NICE CG154 / RCOG GTG 21