Hormone replacement / oestrogen
Conjugated oestrogens
Brand names: Premarin
Adult dose
Dose: HRT: 0.3–1.25mg OD. Atrophic vaginitis topical: as directed
Route: PO/Topical (vaginal)
Frequency: OD
Clinical pearls
- Add progestogen if uterus present (endometrial protection)
- Lowest effective dose, shortest duration
Contraindications
- Oestrogen-dependent malignancy
- Undiagnosed vaginal bleeding
- Active VTE
- Active liver disease
- Pregnancy
Side effects
- Breast tenderness
- Nausea
- VTE
- Stroke
- Endometrial cancer (unopposed in women with uterus)
- Breast cancer (combined HRT)
Interactions
- Enzyme inducers reduce effect
Reference: BNF; NICE NG23; https://bnf.nice.org.uk/drugs/conjugated-oestrogens/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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