Cryoprecipitate Dose Calculator for Fibrinogen Replacement
Calculates number of cryoprecipitate pools required to raise fibrinogen to target level. Treatment of choice for acquired hypofibrinogenaemia in DIC, massive haemorrhage, obstetric haemorrhage, and liver disease. In the UK each pool contains 5 units; each unit raises plasma fibrinogen approximately 0.1 g/L per 70 kg adult.
Score interpretation
Low dose cryoprecipitate: 1-2 pools (5-10 units)
→ Administer cryoprecipitate IV as fast infusion over 5-10 minutes; recheck fibrinogen 30-60 minutes post-transfusion; request via transfusion laboratory (requires group and screen); document indication, batch numbers, and patient consent.
Moderate dose: 3-4 pools (15-20 units) -- notify haematology
→ Discuss with haematologist or haemostasis team; administer over 15-30 minutes; consider concurrent FFP if INR/APTT also abnormal; monitor fibrinogen response at 30-minute intervals; fibrinogen concentrate (Haemocomplettan) may be preferable in obstetric haemorrhage due to pathogen reduction.
Large cryoprecipitate requirement -- major haemostatic compromise
→ Urgent haematologist involvement; activate massive haemorrhage protocol; consider fibrinogen concentrate (Haemocomplettan 3-4 g IV) as faster alternative; concurrent FFP, platelets, and packed RBCs in 1:1:1:1 ratio; TEG/ROTEM-guided therapy if available; consider TXA if within 3 hours of bleeding onset (1 g IV over 10 min plus 1 g over 8 hours); ICU involvement.
Interpretation bands for the Cryoprecipitate Dosing. Apply clinical judgement and local guidance.
References
- NICE NG24. Blood transfusion. NICE. 2015 (updated 2023).
- Hunt BJ et al. A practical guideline for the haematological management of major haemorrhage. Br J Haematol. 2015;170(6):788-803.
Related
Curated clinical cross-links plus same-class fallbacks.
- Corrected Count Increment (CCI) for Platelet Transfusion · Transfusion Medicine
- ABC Score for Massive Transfusion · Transfusion Medicine
- Maximum Allowable Blood Loss · Transfusion Medicine
- Blood Volume Calculation (Nadler Formula) · Transfusion Medicine
- Sickle Cell Exchange Transfusion Volume · Transfusion Medicine
- Fresh Frozen Plasma (FFP) Dose Calculator · Transfusion Medicine
- Fibrinogen Concentrate · Coagulation Factor Replacement — Hypofibrinogenaemia
- Dopamine (ICU — Vasopressor/Inotrope) · Catecholamine (Dose-Dependent Vasopressor/Inotrope)
- Hydroxocobalamin (High-Dose — Cyanide Antidote) · Cyanide Antidote (Vitamin B12 Precursor at High Dose)
- Dopamine hydrochloride · Inotrope / vasopressor (dose-dependent)
- Enalapril with hydrochlorothiazide · ACE inhibitor + thiazide diuretic (fixed-dose)
- Amiloride with Bumetanide · Potassium-Sparing Diuretic + Loop Diuretic (Fixed-Dose Combination)
- Major Haemorrhage / Massive Transfusion · BCSH; RCOA; RCEM; RCS — BCSH Guidelines
- Anaemia Investigation · BSH / NICE
- Splenomegaly Workup · BSH; BMJ Best Practice
- Deep Vein Thrombosis Diagnosis and Treatment · NICE CG144 / NICE NG158
- Sickle Cell Crisis · BSH 2021 / BCSH
- Neutropenic Sepsis · NICE CG151 2012 / ESMO
Decision support only — verify against a current formulary, NICE, or your local guideline before clinical use.