Combined HRT
Conjugated oestrogens with medroxyprogesterone
Brand names: Premique
Adult dose
Dose: 1 tab OD continuously
Route: PO
Frequency: OD
Clinical pearls
- Postmenopausal women with intact uterus
Contraindications
- As conjugated oestrogens
- Severe hepatic disease
- Active or hx breast cancer
Side effects
- As conjugated oestrogens; combined HRT slightly increased breast cancer risk vs oestrogen alone
Interactions
- Enzyme inducers
Reference: BNF; NICE NG23; https://bnf.nice.org.uk/drugs/conjugated-oestrogens-with-medroxyprogesterone/. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
Pathways
- Spinal Anaesthesia Hypotension Management · AAGBI; ASA
- Pre-Eclampsia / Eclampsia in ED · NICE NG133; RCOG Green-top 10A
- Suspected Ectopic Pregnancy · NICE NG126; RCOG Green-top 21
- Polycystic Ovary Syndrome (PCOS) · International PCOS Guideline 2023; NICE CKS
- Pre-eclampsia Management · NICE NG133 2019
- Ectopic Pregnancy · NICE CG154 / RCOG GTG 21