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Synthetic prostaglandin E1 analogue

Gemeprost

Brand names: Cervagem

Adult dose

Dose: 1mg PV every 3h up to 5 doses (1st trimester); 1mg PV every 3h up to 5 doses, repeated next day if needed (2nd trimester)
Route: PV
Frequency: 3-hourly

Clinical pearls

  • Cervical priming and termination of pregnancy
  • Largely superseded by misoprostol (off-label, lower cost)

Contraindications

  • Glaucoma
  • Severe asthma
  • Bronchospasm
  • Cardiovascular disease
  • Hypersensitivity

Side effects

  • Uterine pain
  • GI upset
  • Vaginal bleeding
  • Hypotension
  • Bronchospasm
  • MI (rare)

Interactions

  • Oxytocin (potentiation)

Monitoring

  • BP
  • Bleeding

Reference: BNF; RCOG guidance; https://bnf.nice.org.uk/drugs/gemeprost/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.

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