Recombinant human luteinising hormone (rLH)

Lutropin alfa

Brand names: Luveris

Adult dose

Dose: 75 IU SC OD with follitropin alfa for follicular development

Route: Subcutaneous

Frequency: OD

Clinical pearls

Specialist fertility clinic prescribing
Used in severe FSH/LH deficiency (hypogonadotropic hypogonadism) for ovulation induction
HFEA-licensed assisted conception unit context
NICE CG156 fertility guidance

Contraindications

Ovarian/uterine/breast cancer
Pituitary or hypothalamic tumour
Undiagnosed gynaecological bleeding
Primary ovarian failure
Pregnancy
Hypersensitivity

Side effects

Ovarian hyperstimulation syndrome (OHSS)
Multiple pregnancy
Ectopic pregnancy
Injection-site reactions
Ovarian torsion
Thromboembolism

Interactions

Other gonadotropins (additive)

Monitoring

Ovarian response (ultrasound, oestradiol)
OHSS symptoms

Reference: BNF; NICE CG156; HFEA; SmPC; https://bnf.nice.org.uk/drugs/lutropin-alfa/. Verify against your local formulary and the latest BNF before prescribing.

Curated clinical cross-links plus same-class fallbacks.

Pathways