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Phosphate replacement

Phosphate

Brand names: Phosphate Sandoz, Phosphate-binders see separate entries

Adult dose

Dose: Hypophosphataemia mild: 1–2 effervescent tabs (16.1 mmol phosphate) TDS PO. Severe (<0.3 mmol/L): 9–18 mmol IV over 12h
Route: PO/IV
Frequency: per indication

Clinical pearls

  • Refeeding syndrome — replace early per NICE NG32
  • Severe (<0.3 mmol/L) requires IV cautious replacement

Contraindications

  • Hyperphosphataemia
  • Severe renal impairment (without monitoring)
  • Hypoparathyroidism
  • Hypercalcaemia

Side effects

  • Diarrhoea (PO)
  • Hypocalcaemia
  • Hyperkalaemia (with K+ phosphate)
  • Soft-tissue calcification (severe)

Interactions

  • Calcium-containing antacids
  • Iron
  • Tetracyclines
  • Quinolones (separate doses)

Monitoring

  • Phosphate
  • Calcium
  • K+
  • U&E

Reference: BNF; NICE NG32; UK guidelines; https://bnf.nice.org.uk/drugs/phosphate/. Verify against your local formulary and the latest BNF before prescribing.

Related

Curated clinical cross-links plus same-class fallbacks.