Irreversible ErbB family TKI
Afatinib [Specialist drug]
Brand names: Giotrif
Adult dose
Dose: Specialist; typically 40 mg OD on empty stomach
Route: Oral
Frequency: Per SACT/SmPC
Clinical pearls
- EGFR-mutant NSCLC; defer dosing to BNF/SmPC and SACT
Contraindications
- Severe hepatic impairment (caution)
Side effects
- Diarrhoea
- Rash/acneiform
- Stomatitis
- ILD
Interactions
- P-gp inhibitors/inducers
Monitoring
- LFTs, U&E
- Skin/GI toxicity
Reference: BNF; NICE TA310/TA422; ESMO; SmPC Giotrif. Verify against your local formulary and the latest BNF before prescribing.
Related
Curated clinical cross-links plus same-class fallbacks.
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